Hprt1^{tm1(tetO-Runx1,-EGFP)Enk}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(tetO-Runx1,-EGFP)Enk}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Elena N Kozlova
• MGI ID: MGI:4840037
• Synonyms: HPRT-Runx1a-IRES-EGFP
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(tetO-Runx1,-EGFP)Enk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165939
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Hprt1^{tm1(tetO-Runx1,-EGFP)Enk} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Runx1 (MGI:99852)

• Mutation details: A cassette containing the tetracycline-responsive element (TRE) driving inducible expression of the mouse cDNA and an IRES/EGFP were inserted into the locus. (J:165939)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:165939 Kanaykina N, et al., In vitro and in vivo effects on neural crest stem cell differentiation by conditional activation of Runx1 short isoform and its effect on neuropathic pain behavior. Ups J Med Sci. 2010 Feb;115(1):56-64
• All: 1 reference(s)