About   Help   FAQ
Meg3tm1Itl
Targeted Allele Detail
Summary
Symbol: Meg3tm1Itl
Name: maternally expressed 3; targeted mutation 1, inGenious Targeting Laboratory
MGI ID: MGI:4840060
Synonyms: Meg3tm1Igl
Gene: Meg3  Location: Chr12:109506879-109538163 bp, + strand  Genetic Position: Chr12, 60.25 cM
Alliance: Meg3tm1Itl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166176
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 5.9 kb region spanning from about 300 bp upstream of exon 1 to downstream of exon 5 was replaced with a neo cassette via homologous recombination. This deletion includes part but not all of the upstream differentially methylated region. (J:166176)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 104 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Meg3 Mutation:  4 strains or lines available
References
Original:  J:166176 Zhou Y, et al., Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development. 2010 Aug;137(16):2643-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory