Meg3^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Meg3^tm1Itl
• Name: maternally expressed 3; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:4840060
• Synonyms: Meg3^tm1Igl
• Gene: Meg3 Location: Chr12:109506879-109538163 bp, + strand Genetic Position: Chr12, 60.25 cM
• Alliance: Meg3^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166176
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.9 kb region spanning from about 300 bp upstream of exon 1 to downstream of exon 5 was replaced with a neo cassette via homologous recombination. This deletion includes part but not all of the upstream differentially methylated region. (J:166176)

Expression

In Mice Carrying this Mutation:	104 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meg3 Mutation: 4 strains or lines available

References

• Original: J:166176 Zhou Y, et al., Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development. 2010 Aug;137(16):2643-52
• All: 2 reference(s)