Lmna^tm7Lgf
Targeted Allele Detail

Summary

• Symbol: Lmna^tm7Lgf
• Name: lamin A; targeted mutation 7, Loren G Fong
• MGI ID: MGI:4840061
• Synonyms: Lmna^LAO
• Gene: Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
• Alliance: Lmna^tm7Lgf page

Misshapen cell nuclei in embryonic Lmna^tm7Lgf/Lmna^tm7Lgf fibroblasts

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165928
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Intragenic deletion Mutation details: Exons 10, 11, and 12 (and the introns between) were replaced with the corresponding cDNA without the last 30 nucleotides of exon 11 and the first 24 nucleotides of exon 12 to bring the last codon of mature lamin A adjacent to the prelamin A stop codon. This allele is predicted to produce only the mature lamin A isoform. (J:165928)

Generation of the Lmna^tm7Lgf allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmna Mutation: 84 strains or lines available

References

• Original: J:165928 Coffinier C, et al., Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem. 2010 Jul 2;285(27):20818-26
• All: 3 reference(s)