Plcg2^Ali14
Chemically induced Allele Detail

Summary

• Symbol: Plcg2^Ali14
• Name: phospholipase C, gamma 2; Abnormal limb 14
• MGI ID: MGI:4840229
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^Ali14 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Identified as part of a dominant dysmorphology screen of ENU induced mutations. Tyrosine 495 in the spPH domain is replaced by Cysteine. (J:166106)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 74 strains or lines available

References

• Original: J:166106 Everett KL, et al., Characterization of phospholipase C gamma enzymes with gain-of-function mutations. J Biol Chem. 2009 Aug 21;284(34):23083-93
• All: 3 reference(s)