L3mbtl1^tm1.1Haho
Targeted Allele Detail

Summary

• Symbol: L3mbtl1^tm1.1Haho
• Name: L3MBTL1 histone methyl-lysine binding protein; targeted mutation 1.1, Hanno Hock
• MGI ID: MGI:4840260
• Gene: L3mbtl1 Location: Chr2:162785392-162816442 bp, + strand Genetic Position: Chr2, 83.88 cM
• Alliance: L3mbtl1^tm1.1Haho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166180
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT-flanked neo cassette with a 3'UTR was inserted downstream of exon 12 and an additional loxP site was inserted downstream of exon 21. Cre-mediated recombination removed exons 13 through 20. The absence of protein expression was confirmed by western blot analysis on brain, testis, and embryonic stem cell extracts. (J:166180)

Generation of the L3mbtl1^tm1.1Haho allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any L3mbtl1 Mutation: 43 strains or lines available

References

• Original: J:166180 Qin J, et al., Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. J Biol Chem. 2010 Sep 3;285(36):27767-75
• All: 3 reference(s)