Adgra2^tm1Cjku
Targeted Allele Detail

Summary

• Symbol: Adgra2^tm1Cjku
• Name: adhesion G protein-coupled receptor A2; targeted mutation 1, Calvin J Kuo
• MGI ID: MGI:4840264
• Synonyms: GPR124^lacZ
• Gene: Adgra2 Location: Chr8:27575611-27613464 bp, + strand Genetic Position: Chr8, 15.91 cM, cytoband A3
• Alliance: Adgra2^tm1Cjku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon was replaced with a lacZ/neo cassette. Quantitative RT-PCR, northern and western blot analysis confirmed the absence of RNA and protein expression in homozygous embryos. LacZ expression is detected in the vasculature in heterozygous embryos at E10.5. (J:166127)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgra2 Mutation: 43 strains or lines available

References

• Original: J:166127 Kuhnert F, et al., Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12;330(6006):985-9
• All: 4 reference(s)