Ntrk2^tm2.1Mini
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm2.1Mini
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 2.1, Liliana Minichiello
• MGI ID: MGI:4840323
• Synonyms: TrkB^D
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm2.1Mini page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132562
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions result in the amino acid substitutions of phenylalanine for tyrosine at positions 515 and 816 (Y515F and Y816F). A floxed allele neo cassette inserted downstream of the modified cDNA was removed by cre mediated recombination. (J:132562)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:132562 Medina DL, et al., TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration. EMBO J. 2004 Oct 1;23(19):3803-14
• All: 3 reference(s)