Tnfsf11^{tm1(TNFSF11)Kost}
Targeted Allele Detail

Summary

• Symbol: Tnfsf11^{tm1(TNFSF11)Kost}
• Name: tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Paul J Kostenuik
• MGI ID: MGI:4840355
• Synonyms: huRANKL, Tnfrsf11a^tm1Kost
• Gene: Tnfsf11 Location: Chr14:78514886-78545483 bp, - strand Genetic Position: Chr14, 41.26 cM
• Alliance: Tnfsf11^{tm1(TNFSF11)Kost} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166279
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Tnfsf11^{tm1(TNFSF11)Kost} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNFSF11 (8600)

  Tnfsf11

  (MGI:1100089)

• Mutation details: The coding region of the endogenous exon 5 of the mouse gene was replaced with the coding region of exon 5 of the human gene. A floxed PGK-neomycin selection cassette was also inserted downstream of exon 5. (J:166279)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf11 Mutation: 32 strains or lines available

References

• Original: J:166279 Kostenuik PJ, et al., Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL. J Bone Miner Res. 2009 Feb;24(2):182-95
• All: 3 reference(s)