Sh2d1b1/Sh2d1b2^tm1.1Cpt
Targeted Allele Detail

Summary

• Symbol: Sh2d1b1/Sh2d1b2^tm1.1Cpt
• Name: SH2 domain containing 1B2; targeted mutation 1.1, Cox Terhorst
• MGI ID: MGI:4840396
• Synonyms: EAT-2A/B^-
• Gene: Sh2d1b2 Location: Chr1:170060440-170079156 bp, + strand Genetic Position: Chr1, 76.84 cM
• Alliance: Sh2d1b1/Sh2d1b2^tm1.1Cpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166054
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 of Sh2d1b1 was replaced with a floxed neo cassette while exon 1 of Sh2d1b2 was replaced with a hygro cassette with a 5' loxP site. Cre mediated recombination removed the intervening sequence. (J:166054)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d1b2 Mutation: 8 strains or lines available

References

• Original: J:166054 Wang N, et al., Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse. J Immunol. 2010 Nov 15;185(10):5683-7
• All: 3 reference(s)