Trp53^tm1.1Xlu
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Xlu
• Name: transformation related protein 53; targeted mutation 1.1, Xin Lu
• MGI ID: MGI:4840439
• Synonyms: p53^312A, S312A, Trp53^tm1.1Igl, Trp53^tm1.1Itl
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Xlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166152
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 9 was replaced with one in which nucleotide substitutions (TCT-to-GCC) resulting in the amino acid substitution of serine with alanine at position 312 (p.S312A). A loxP site flanked neomycin resistance gene cassette inserted downstream of the modified exon 9 was removed by Cre-mediated recombination. (J:166152)

Generation of the Trp53^tm1.1Xlu allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 239 strains or lines available

References

• Original: J:166152 Slee EA, et al., Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19479-84
• All: 2 reference(s)