Rxfp2^m1Lja
Chemically induced Allele Detail

Summary

• Symbol: Rxfp2^m1Lja
• Name: relaxin/insulin-like family peptide receptor 2; mutation 1, J Larry Jameson
• MGI ID: MGI:4840457
• Synonyms: line 1061, Rxfp2^DG, Rxfp2^m1Jmsn
• Gene: Rxfp2 Location: Chr5:149942140-150005649 bp, + strand Genetic Position: Chr5, 89.23 cM
• Alliance: Rxfp2^m1Lja page

Small testes and spermatogenesis defects in Rxfp2^m1Lja/Rxfp2^m1Lja mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a A to G in exon 12 that results in the amino acid substitution of glycine for aspartic acid at position 294 (D294G). This subsitution is located within the eighth N-terminal leucine rich repeat. (J:166053)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxfp2 Mutation: 53 strains or lines available

References

• Original: J:166053 Harris RM, et al., A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism. Mamm Genome. 2010 Oct;21(9-10):442-9
• All: 2 reference(s)