Nfat5^tm1.1Joar
Targeted Allele Detail

Summary

• Symbol: Nfat5^tm1.1Joar
• Name: nuclear factor of activated T cells 5; targeted mutation 1.1, Jose Aramburu
• MGI ID: MGI:4840524
• Synonyms: NFAT5^Flox
• Gene: Nfat5 Location: Chr8:108020102-108106149 bp, + strand Genetic Position: Chr8, 53.93 cM, cytoband D2
• Alliance: Nfat5^tm1.1Joar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148271
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 6 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 6. Flp mediated recombination removed the neo cassette leaving exon 6 floxed. (J:148271)

Generation of the floxed Nfat5^tm1.1Joar allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfat5 Mutation: 67 strains or lines available

References

• Original: J:148271 Drews-Elger K, et al., The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS One. 2009;4(4):e5245
• All: 6 reference(s)