Cars2^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Cars2^m1Btlr
• Name: cysteinyl-tRNA synthetase 2, mitochondrial; mutation 1, Bruce Beutler
• MGI ID: MGI:4840539
• Synonyms: madcow
• Gene: Cars2 Location: Chr8:11564017-11600781 bp, - strand Genetic Position: Chr8, 5.73 cM, cytoband A2
• Alliance: Cars2^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, in the ninth of the gene's 15 exons, corresponds to a T to A transversion at nucleotide position 1007 of the transcript (GenBank Accession NM_024248). It is predicted to result in replacement of serine by threonine at amino acid position 305 of the protein (S305T), in the conserved KMSKS motif. (J:167594)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cars2 Mutation: 30 strains or lines available

References

• Original: J:167594 Eidenschenk C, et al., Madcow, a mutation in the mitochondrial cysteinyl-tRNA synthetase gene, results in an age-related neurobehavioral phenotype. MGI Direct Data Submission. 2011
• All: 1 reference(s)