Dph2^{tm2(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Dph2^{tm2(EUCOMM)Wtsi}
• Name: DPH2 homolog; targeted mutation 2, Wellcome Trust Sanger Institute
• MGI ID: MGI:4840638
• Gene: Dph2 Location: Chr4:117745838-117749220 bp, - strand Genetic Position: Chr4, 53.74 cM
• Alliance: Dph2^{tm2(EUCOMM)Wtsi} page
• IMPC: Dph2 gene page

Mutation origin

• Mutant Cell Lines: EPD0438_5_C04, EPD0438_5_G07
• Germline Transmission: Earliest citation of germline transmission: J:175295
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 1973 starting at position 117746669 and ending at position 117748642 of Chromosome 4 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 1 line available
• Carrying any Dph2 Mutation: 19 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 5 reference(s)