Katnal2tm1a(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Katnal2tm1a(EUCOMM)Wtsi |
Name: |
katanin p60 subunit A-like 2; targeted mutation 1a, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:4842422 |
Synonyms: |
Katnal2KO |
Gene: |
Katnal2 Location: Chr18:77064844-77135004 bp, - strand Genetic Position: Chr18, 52.02 cM, cytoband E3
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Alliance: |
Katnal2tm1a(EUCOMM)Wtsi page
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IMPC: |
Katnal2 gene page |
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Spermiation and spermatid defects in Katnal2m1Anu/Katnal2tm1a(EUCOMM)Wtsi mice
Show the 2 phenotype image(s) involving this allele.
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Mutant Cell Lines: |
EPD0656_4_A03, EPD0656_4_A04, EPD0656_4_B03, EPD0656_4_B04, EPD0656_4_C03, EPD0656_4_D02, EPD0656_4_D04, EPD0656_4_E02, EPD0656_4_E03, EPD0656_4_F01, EPD0656_4_F02, EPD0656_4_F03, EPD0656_4_G01, EPD0656_4_H02, EPD0656_4_H04 |
Germline Transmission: |
Earliest citation of germline transmission:
J:250115
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready, Null/knockout, Reporter) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 77104991 of Chromosome 18 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 77105793. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:155845, J:173534, J:250115)
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Schematic of the Katnal2tm1a(EUCOMM)Wtsi knockout first, conditional-ready allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010; |
All: |
4 reference(s) |
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