Lgals8^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Lgals8^{tm1(KOMP)Vlcg}
• Name: lectin, galactose binding, soluble 8; targeted mutation 1, Velocigene
• MGI ID: MGI:4842980
• Synonyms: Lgals8^-
• Gene: Lgals8 Location: Chr13:12454296-12479825 bp, - strand Genetic Position: Chr13, 4.64 cM
• Alliance: Lgals8^{tm1(KOMP)Vlcg} page
• IMPC: Lgals8 gene page

Lymphangiogenesis and severity of herpes simplex virus-induced keratitis and suture-induced inflammatory lymphangiogenesis is reduced in Lgals8^{tm1(KOMP)Vlcg}/Lgals8^{tm1(KOMP)Vlcg} mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Lines: 14305A-F8, 14305C-B4
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 18427bp between positions 12455667-12474093 of Chromosome 13 (Build GRCm39). Western blot analysis of liver tissue lysates confirmed the absence of protein expression in homozygous mutant mice. (J:136110, J:235778)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Lgals8 Mutation: 34 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 9 reference(s)