Pkd2^tm1.1Tjwt
Targeted Allele Detail

Summary

• Symbol: Pkd2^tm1.1Tjwt
• Name: polycystin 2, transient receptor potential cation channel; targeted mutation 1.1, Terry J Watnick
• MGI ID: MGI:4843126
• Synonyms: Pkd2^cond, Pkd2^deltaneo, Pkd2^{flox11-13deltaneo}, Pkd2^tm1.1Tjw
• Gene: Pkd2 Location: Chr5:104607316-104653685 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Pkd2^tm1.1Tjwt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165114
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 11 and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 13. Flp-mediated recombination removed the neo cassette leaving exons 11 through 13 floxed. (J:165114)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pkd2 Mutation: 85 strains or lines available

References

• Original: J:165114 Garcia-Gonzalez MA, et al., Pkd1 and Pkd2 are required for normal placental development. PLoS One. 2010;5(9)
• All: 8 reference(s)