Pkd2^tm1.2Tjwt
Targeted Allele Detail

Summary

• Symbol: Pkd2^tm1.2Tjwt
• Name: polycystin 2, transient receptor potential cation channel; targeted mutation 1.2, Terry J Watnick
• MGI ID: MGI:4843127
• Synonyms: Pkd2^delta11-13
• Gene: Pkd2 Location: Chr5:104607316-104653685 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Pkd2^tm1.2Tjwt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165114
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 11 through 13 from Pkd2^tm1.1Tjwt. The absence of protein expression was confirmed by western blot analysis on embryo extracts. (J:165114)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd2 Mutation: 85 strains or lines available

References

• Original: J:165114 Garcia-Gonzalez MA, et al., Pkd1 and Pkd2 are required for normal placental development. PLoS One. 2010;5(9)
• All: 5 reference(s)