Pcid2^tm1Imku
Targeted Allele Detail

Summary

• Symbol: Pcid2^tm1Imku
• Name: PCI domain containing 2; targeted mutation 1, Nobuo Sakaguchi
• MGI ID: MGI:4843141
• Gene: Pcid2 Location: Chr8:13127189-13155459 bp, - strand Genetic Position: Chr8, 5.73 cM
• Alliance: Pcid2^tm1Imku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166080
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance gene was inserted in intron 1 and a third loxP sited was placed in the HindIII site 5' to exon 1. (J:166080)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcid2 Mutation: 17 strains or lines available

References

• Original: J:166080 Nakaya T, et al., Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. J Immunol. 2010 Nov 1;185(9):5180-7
• All: 2 reference(s)