Lepr^tm4Mgmj
Targeted Allele Detail

Summary

• Symbol: Lepr^tm4Mgmj
• Name: leptin receptor; targeted mutation 4, Martin G Myers, Jr
• MGI ID: MGI:4843181
• Synonyms: LepRb^delta65
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm4Mgmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164339
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 18 was replaced with one that lacks the coding sequence for the C-terminal 65 amino acids. While all motifs required for Jak2 association and activation remain all other intracellular sequences are deleted. (J:164339)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:164339 Robertson S, et al., Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes. 2010 Apr;59(4):782-90
• All: 1 reference(s)