Tg(Lck-Notch3)#Issc
Transgene Detail

Summary

• Symbol: Tg(Lck-Notch3)#Issc
• Name: transgene insertion, Isabella Screpanti
• MGI ID: MGI:4843437
• Synonyms: Notch3-IC, Notch3 tg(+), tg N3-IC
• Transgene: Tg(Lck-Notch3)#Issc Location: unknown
• Alliance: Tg(Lck-Notch3)#Issc page

Transgene origin

• Strain of Origin: (DBA/2 x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Notch3)#Issc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Notch3 (MGI:99460)

• Mutation details: The mouse promoter drives thymocyte-specific expression of a truncated mouse cDNA encoding the intracellular domain with an HA tag and human growth hormone sequences and polyadenylation site. Fourteen founders were established. # is used when no specifc line is designated. (J:63300)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:63300 Bellavia D, et al., Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in notch3 transgenic mice. EMBO J. 2000 Jul 3;19(13):3337-48
• All: 14 reference(s)