Kras^tm2Bbd
Targeted Allele Detail

Summary

• Symbol: Kras^tm2Bbd
• Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 2, Mariano Barbacid
• MGI ID: MGI:4844115
• Synonyms: K-Ras^lox
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^tm2Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161780
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• No details provided. (J:161780)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 84 strains or lines available

References

• Original: J:161780 Puyol M, et al., A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell. 2010 Jul 13;18(1):63-73
• All: 11 reference(s)