Pik3ca^tm1.1Rzl
Targeted Allele Detail

Summary

• Symbol: Pik3ca^tm1.1Rzl
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1.1, Richard Z Lin
• MGI ID: MGI:4845856
• Synonyms: p110alpha^flox, p110^alphaFlox, pik3ca1 loxP, Pik3ca^Flox
• Gene: Pik3ca Location: Chr3:32451203-32520256 bp, + strand Genetic Position: Chr3, 15.7 cM, cytoband B
• Alliance: Pik3ca^tm1.1Rzl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166421
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1, and an FRT and loxP flanked neo cassette was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette leaving exon 1 floxed. (J:166421)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3ca Mutation: 66 strains or lines available

References

• Original: J:166421 Lu Z, et al., Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction. Circulation. 2009 Jul 28;120(4):318-25
• All: 11 reference(s)