Pik3cb^tm1.1Rzl
Targeted Allele Detail

Summary

• Symbol: Pik3cb^tm1.1Rzl
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1.1, Richard Z Lin
• MGI ID: MGI:4845857
• Synonyms: p110^betaflox, pik3cb3/4 loxP, Pik3cb^Flox
• Gene: Pik3cb Location: Chr9:98920455-99022264 bp, - strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Pik3cb^tm1.1Rzl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166421
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3, and an FRT and loxP flanked neo cassette was inserted downstream of exon 4. Flp mediated recombination removed the neo cassette leaving exons 3 and 4 floxed. (J:166421)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3cb Mutation: 152 strains or lines available

References

• Original: J:166421 Lu Z, et al., Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction. Circulation. 2009 Jul 28;120(4):318-25
• All: 9 reference(s)