Havcr1^tm1Shw
Targeted Allele Detail

Summary

• Symbol: Havcr1^tm1Shw
• Name: hepatitis A virus cellular receptor 1; targeted mutation 1, See Heng Wong
• MGI ID: MGI:4845870
• Synonyms: Tim-1^-
• Gene: Havcr1 Location: Chr11:46630644-46670405 bp, + strand Genetic Position: Chr11, 28.08 cM
• Alliance: Havcr1^tm1Shw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166400
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into exon 2. The absence of transcript expression was confirmed by RT-PCR on liver, lung, heart, mononuclear cells, spleen, thymus, and kidney extracts. (J:166400)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Havcr1 Mutation: 29 strains or lines available

References

• Original: J:166400 Wong SH, et al., Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response. Immunology. 2010 Sep;131(1):77-88
• All: 4 reference(s)