Ep400^tm3Fuku
Targeted Allele Detail

Summary

• Symbol: Ep400^tm3Fuku
• Name: E1A binding protein p400; targeted mutation 3, Rikiro Fukunaga
• MGI ID: MGI:4845874
• Synonyms: mDom^fl
• Gene: Ep400 Location: Chr5:110812239-110918583 bp, - strand Genetic Position: Chr5, 53.69 cM, cytoband F
• Alliance: Ep400^tm3Fuku page

Loss of bone marrow hematopoietic cells in Ep400^tm3Fuku/Ep400^tm3.1Fuku Tg(Mx1-cre)1Cgn/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166397
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 15, and an FRT and loxP flanked neo cassette was inserted downstream of exon 15. Flp-mediated recombination removed the neo cassette leaving exon 15 floxed. (J:166397)

Generation of the Ep400^tm3Fuku and Ep400^tm3.1Fuku alleles

Expression

In Mice Carrying this Mutation:

10 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ep400 Mutation: 142 strains or lines available

References

• Original: J:166397 Fujii T, et al., Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression. J Biol Chem. 2010 Sep 24;285(39):30214-23
• All: 4 reference(s)