Pim2^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Pim2^tm1.1Lex
• Name: proviral integration site 2; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:4847572
• Gene: Pim2 Location: ChrX:7744545-7749671 bp, + strand Genetic Position: ChrX, 3.55 cM
• Alliance: Pim2^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exons 1 through 3 and the neo cassette. The absence of transcript expression was confirmed. (J:166403)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pim2 Mutation: 7 strains or lines available

References

• Original: J:166403 Yang J, et al., Proviral integration site 2 is required for interleukin-6 expression induced by interleukin-1, tumour necrosis factor-alpha and lipopolysaccharide. Immunology. 2010 Oct;131(2):174-82
• All: 1 reference(s)