Ackr4^tm1.1Rjbn
Targeted Allele Detail

Summary

• Symbol: Ackr4^tm1.1Rjbn
• Name: atypical chemokine receptor 4; targeted mutation 1.1, Robert J B Nibbs
• MGI ID: MGI:4847614
• Synonyms: CCRL1^-
• Gene: Ackr4 Location: Chr9:103974881-104003842 bp, - strand Genetic Position: Chr9, 56.47 cM
• Alliance: Ackr4^tm1.1Rjbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166490
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by RT-PCR on thymus and heart extracts. (J:166490)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ackr4 Mutation: 25 strains or lines available

References

• Original: J:166490 Comerford I, et al., The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses. Blood. 2010 Nov 18;116(20):4130-40
• All: 13 reference(s)