Ctsg^{tm3.1(PML/RARA)Ley}
Targeted Allele Detail

Summary

• Symbol: Ctsg^{tm3.1(PML/RARA)Ley}
• Name: cathepsin G; targeted mutation 3.1, Timothy J Ley
• MGI ID: MGI:4847629
• Synonyms: mCG-PR2VR, PR^2VR
• Gene: Ctsg Location: Chr14:56337342-56340031 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Ctsg^{tm3.1(PML/RARA)Ley} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166479
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A cDNA encoding the human PML-RARA fusion with nucleotide substitution resulting in the amino acid substitutions of arginine for valine at positions 420 and 432 (V420 and V423R) was inserted into the 5'UTR along with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The amino acid substitutions generate a protease cleavage-resistant PML-RARA product. (J:166479)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsg Mutation: 13 strains or lines available

References

• Original: J:166479 Uy GL, et al., A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia. Blood. 2010 Nov 4;116(18):3604-10
• All: 1 reference(s)