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Tbk1tm1.1Lex
Targeted Allele Detail
Summary
Symbol: Tbk1tm1.1Lex
Name: TANK-binding kinase 1; targeted mutation 1.1, Lexicon Genetics
MGI ID: MGI:4847640
Synonyms: Tbk1delta
Gene: Tbk1  Location: Chr10:121382360-121422692 bp, - strand  Genetic Position: Chr10, 69.84 cM
Alliance: Tbk1tm1.1Lex page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166476
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed the neo cassette and exon 2. Western blot analysis confirmed low levels of protein expression in whole cell lysate extracts. Enzymatic assay confirmed that this truncated protein lacks catalytic activity. (J:166476)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbk1 Mutation:  56 strains or lines available
References
Original:  J:166476 Marchlik E, et al., Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol. 2010 Dec;88(6):1171-80
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory