Tbk1tm1.1Lex
Targeted Allele Detail
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Symbol: |
Tbk1tm1.1Lex |
Name: |
TANK-binding kinase 1; targeted mutation 1.1, Lexicon Genetics |
MGI ID: |
MGI:4847640 |
Synonyms: |
Tbk1delta |
Gene: |
Tbk1 Location: Chr10:121382360-121422692 bp, - strand Genetic Position: Chr10, 69.84 cM
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Alliance: |
Tbk1tm1.1Lex page
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Germline Transmission: |
Earliest citation of germline transmission:
J:166476
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Parent Cell Line: |
Lex-1 (ES Cell)
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Strain of Origin: |
129S5/SvEvBrd
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Project Collection: |
Lexicon
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Allele Type: |
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Targeted (Hypomorph) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Cre-mediated recombination removed the neo cassette and exon 2. Western blot analysis confirmed low levels of protein expression in whole cell lysate extracts. Enzymatic assay confirmed that this truncated protein lacks catalytic activity.
(J:166476)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tbk1 Mutation: |
56 strains or lines available
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Original: |
J:166476 Marchlik E, et al., Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol. 2010 Dec;88(6):1171-80 |
All: |
4 reference(s) |
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