Sct^tm1.1Bkcc
Targeted Allele Detail

Summary

• Symbol: Sct^tm1.1Bkcc
• Name: secretin; targeted mutation 1.1, Billy K C Chow
• MGI ID: MGI:4847670
• Gene: Sct Location: Chr7:140858243-140859046 bp, - strand Genetic Position: Chr7, 86.59 cM, cytoband F5
• Alliance: Sct^tm1.1Bkcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166370
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exons 1 through 4. (J:166370)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sct Mutation: 11 strains or lines available

References

• Original: J:166370 Lee VH, et al., An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II. FASEB J. 2010 Dec;24(12):5024-32
• All: 7 reference(s)