Sirt6^tm1.1Cxd
Targeted Allele Detail

Summary

• Symbol: Sirt6^tm1.1Cxd
• Name: sirtuin 6; targeted mutation 1.1, Chu-Xia Deng
• MGI ID: MGI:4847905
• Synonyms: Sirt6^C, Sirt6^Co
• Gene: Sirt6 Location: Chr10:81457621-81463631 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Sirt6^tm1.1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166368
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 3. Cre mediated recombination removed the selection cassette. (J:166368)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sirt6 Mutation: 41 strains or lines available

References

• Original: J:166368 Kim HS, et al., Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 2010 Sep 8;12(3):224-36
• All: 54 reference(s)