Thra^tm4.1Ven
Targeted Allele Detail

Summary

• Symbol: Thra^tm4.1Ven
• Name: thyroid hormone receptor alpha; targeted mutation 4.1, Bjorn Vennstrom
• MGI ID: MGI:4847930
• Synonyms: TRalpha1-GFP, TRalpha1-GFP-knock-in
• Gene: Thra Location: Chr11:98631539-98659832 bp, + strand Genetic Position: Chr11, 62.58 cM, cytoband D-E
• Alliance: Thra^tm4.1Ven page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166513
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 9 and the GFP coding sequence was inserted into exon 9 in frame. Cre-mediated recombination removed the neo cassette. (J:166513)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Thra Mutation: 40 strains or lines available

References

• Original: J:166513 Wallis K, et al., The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons. Mol Endocrinol. 2010 Oct;24(10):1904-16
• All: 5 reference(s)