Il6ra^tm1.1Jcbr
Targeted Allele Detail

Summary

• Symbol: Il6ra^tm1.1Jcbr
• Name: interleukin 6 receptor, alpha; targeted mutation 1.1, Jens C Bruning
• MGI ID: MGI:4847943
• Synonyms: Il6-Ralpha^FL
• Gene: Il6ra Location: Chr3:89776631-89820503 bp, - strand Genetic Position: Chr3, 39.19 cM
• Alliance: Il6ra^tm1.1Jcbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166367
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette leaving exons 2 and 3 floxed. (J:166367)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6ra Mutation: 35 strains or lines available

References

• Original: J:166367 Wunderlich FT, et al., Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab. 2010 Sep 8;12(3):237-49
• All: 19 reference(s)