Fth1^tm1.1Lck
Targeted Allele Detail

Summary

• Symbol: Fth1^tm1.1Lck
• Name: ferritin heavy polypeptide 1; targeted mutation 1.1, Lukas C Kuhn
• MGI ID: MGI:4847958
• Synonyms: Fth^lox
• Gene: Fth1 Location: Chr19:9957962-9962462 bp, + strand Genetic Position: Chr19, 6.23 cM, cytoband A-C
• Alliance: Fth1^tm1.1Lck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166515
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Flp-mediated recombination removed the neo cassette leaving the promoter and exon 1 floxed. (J:166515)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fth1 Mutation: 14 strains or lines available

References

• Original: J:166515 Darshan D, et al., Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage. Hepatology. 2009 Sep;50(3):852-60
• All: 25 reference(s)