Magel2^tm1.1Mus
Targeted Allele Detail

Summary

• Symbol: Magel2^tm1.1Mus
• Name: MAGE family member L2; targeted mutation 1.1, Francoise Muscatelli
• MGI ID: MGI:4849506
• Gene: Magel2 Location: Chr7:62026758-62031388 bp, + strand Genetic Position: Chr7, 34.37 cM
• Alliance: Magel2^tm1.1Mus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166548
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 5' portion of the coding region was replaced with a floxed hygro cassette. Cre-mediated recombination removed the hygro cassette. The absence of expression in the brain was confirmed by immunohistochemistry. (J:166548)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Magel2 Mutation: 60 strains or lines available

Notes

Magel2 is only expressed paternally (imprinted maternally).

References

• Original: J:166548 Schaller F, et al., A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene. Hum Mol Genet. 2010 Dec 15;19(24):4895-905
• All: 5 reference(s)