Hprt1^{tm1(CAG-Sox9,-EGFP)Akis}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(CAG-Sox9,-EGFP)Akis}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Andreas Kispert
• MGI ID: MGI:4849516
• Synonyms: Hprt^Sox9
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(CAG-Sox9,-EGFP)Akis} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166547
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Hprt1^{tm1(CAG-Sox9,-EGFP)Akis} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sox9 (MGI:98371)

• Mutation details: Exon 1 was replaced with a CAG promoter, loxP site, neo and stop cassette, loxM site, and an inverted Sox9 cDNA followed by an IRES and EGFP. Cre-mediated recombination is required to achieve expression of Sox9 and EGFP. (J:166547)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:166547 Airik R, et al., Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme. Hum Mol Genet. 2010 Dec 15;19(24):4918-29
• All: 3 reference(s)