Vcp^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Vcp^tm1Itl
• Name: valosin containing protein; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:4849540
• Synonyms: VCP^R155H, Vcp^tm1Igl
• Gene: Vcp Location: Chr4:42979964-43000507 bp, - strand Genetic Position: Chr4, 22.95 cM
• Alliance: Vcp^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166230
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution results in the amino acid substitution of histidine for arginine at position 155 (R155H). A floxed and FRT-flanked neo cassette was inserted downstream of exon 5. (J:166230, J:298865)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vcp Mutation: 52 strains or lines available

References

• Original: J:166230 Badadani M, et al., VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One. 2010;5(10)
• All: 19 reference(s)