Gsdma3^Ae
Chemically induced Allele Detail

Summary

• Symbol: Gsdma3^Ae
• Name: gasdermin A3; alopecia and excoriation
• MGI ID: MGI:4849547
• Synonyms: AE, Gsdma3^T344H
• Gene: Gsdma3 Location: Chr11:98517186-98529052 bp, + strand Genetic Position: Chr11, 62.21 cM
• Alliance: Gsdma3^Ae page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to C transition results in the amino acid substitution of histidine for tyrosine at position 344 (Y344H). (J:166522, J:180149, J:225546)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdma3 Mutation: 26 strains or lines available

References

• Original: J:166522 Li J, et al., Gsdma3 is required for hair follicle differentiation in mice. Biochem Biophys Res Commun. 2010 Dec 3;403(1):18-23
• All: 8 reference(s)