Siglech^tm1.1Cln
Targeted Allele Detail

Summary

• Symbol: Siglech^tm1.1Cln
• Name: sialic acid binding Ig-like lectin H; targeted mutation 1.1, Marco Colonna
• MGI ID: MGI:4849633
• Synonyms: SiglecH-eGFP
• Gene: Siglech Location: Chr7:55417926-55428673 bp, + strand Genetic Position: Chr7, 33.42 cM
• Alliance: Siglech^tm1.1Cln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166504
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: EGFP and a floxed neo cassette were inserted upstream of exon 1. Cre-mediated recombination removed the neo cassette. EGFP expression is high in plasmacytoid dendritic cells and low in classical dendritic cells. (J:166504)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siglech Mutation: 24 strains or lines available

References

• Original: J:166504 Swiecki M, et al., Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity. 2010 Dec 14;33(6):955-66
• All: 3 reference(s)