Slc8a1^m51207Hubr
Chemically induced Allele Detail

Summary

• Symbol: Slc8a1^m51207Hubr
• Name: solute carrier family 8 (sodium/calcium exchanger), member 1; mutation 51207, Hubrecht Institute
• MGI ID: MGI:4849923
• Synonyms: 5120-7, HI-07, Ncx1^N874K, Slc8a1^m1Hubr
• Gene: Slc8a1 Location: Chr17:81680534-82045806 bp, - strand Genetic Position: Chr17, 51.29 cM
• Alliance: Slc8a1^m51207Hubr page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis results in a T to A transversion in exon 9 that results in the amino acid substitution of lysine for asparagine at position 874 (N874K). (J:167034)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc8a1 Mutation: 55 strains or lines available

References

• Original: J:167034 Wansleeben C, et al., A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction. Int J Dev Biol. 2010;54(10):1465-71
• All: 3 reference(s)