Tg(H2-K/Igh-Traf2*)#Ywc
Transgene Detail

Summary

• Symbol: Tg(H2-K/Igh-Traf2*)#Ywc
• Name: transgene insertion, Yongwon Choi
• MGI ID: MGI:4850018
• Synonyms: TRAF2.DN, Traf2DN-tg
• Transgene: Tg(H2-K/Igh-Traf2*)#Ywc Location: unknown
• Alliance: Tg(H2-K/Igh-Traf2*)#Ywc page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K/Igh-Traf2*)#Ywc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Traf2 (MGI:101835)

• Mutation details: The H2-K promoter and an Igh enhancer from the pHSE-3' vector drives B and T cell-specific expression of a fragment of murine Traf2 (241-501), a dominant negative form, tagged with the 1D4-epitope. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:166886)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:166886 Lee SY, et al., TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival. Immunity. 1997 Nov;7(5):703-13
• All: 6 reference(s)