Ighg1^tm4Cgn
Targeted Allele Detail

Summary

• Symbol: Ighg1^tm4Cgn
• Name: immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 4, University of Cologne
• MGI ID: MGI:4850023
• Synonyms: Igh^s-hMT
• Gene: Ighg1 Location: Chr12:113290161-113294143 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighg1^tm4Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166887
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.7 kb sequence directly upstream of the IgG1 switch region and containing all known IL-4 inducible elements in this region was replaced with a neomycin selection cassette in reverse orientation and the human metallothionein II promoter. The splice donor site of the I exon was retained. (J:166887)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighg1 Mutation: 28 strains or lines available

Notes

The ES cells targeted to create this allele were heterozygous for Ighg1.

References

• Original: J:166887 Lorenz M, et al., Switch transcripts in immunoglobulin class switching. Science. 1995 Mar 24;267(5205):1825-8
• All: 1 reference(s)