Pik3cd^tm2.1Tnr
Targeted Allele Detail

Summary

• Symbol: Pik3cd^tm2.1Tnr
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; targeted mutation 2.1, Martin Turner
• MGI ID: MGI:4850049
• Synonyms: p110delta^fl
• Gene: Pik3cd Location: Chr4:149733625-149787023 bp, - strand Genetic Position: Chr4, 80.15 cM
• Alliance: Pik3cd^tm2.1Tnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164283
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and, an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the neo cassette leaving exons 1 through 9 floxed. (J:164283)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3cd Mutation: 45 strains or lines available

References

• Original: J:164283 Rolf J, et al., Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol. 2010 Oct 1;185(7):4042-52
• All: 3 reference(s)