Dchs1^tm1.2Irv
Targeted Allele Detail

Summary

• Symbol: Dchs1^tm1.2Irv
• Name: dachsous cadherin related 1; targeted mutation 1.2, Kenneth Irvine
• MGI ID: MGI:4867020
• Gene: Dchs1 Location: Chr7:105402197-105436861 bp, - strand Genetic Position: Chr7, 55.98 cM
• Alliance: Dchs1^tm1.2Irv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169135
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites and preceded by a 5' FRT-flanked PGK-neomycin cassette. Flp-mediated recombination removed the neo cassette, and cre-mediated recombination removed exon 2. (J:169135)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dchs1 Mutation: 140 strains or lines available

References

• Original: J:169135 Mao Y, et al., Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011 Mar;138(5):947-57
• All: 10 reference(s)