Hadh^tm1Csta
Targeted Allele Detail

Summary

• Symbol: Hadh^tm1Csta
• Name: hydroxyacyl-Coenzyme A dehydrogenase; targeted mutation 1, Charles A Stanley
• MGI ID: MGI:4867189
• Synonyms: SCHAD ko
• Gene: Hadh Location: Chr3:131027068-131065750 bp, - strand Genetic Position: Chr3, 60.86 cM
• Alliance: Hadh^tm1Csta page

Abnormal distribution of alpha-cells throughout the islet in Hadh^tm1Csta/Hadh^tm1Csta mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166803
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was replaced by a neomycin resistance cassette. Protein and mRNA were not detected in any tissue tested. (J:166803)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hadh Mutation: 19 strains or lines available

References

• Original: J:166803 Li C, et al., Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem. 2010 Oct 8;285(41):31806-18
• All: 4 reference(s)