Gsk3b^tm1.1Ypc
Targeted Allele Detail

Summary

• Symbol: Gsk3b^tm1.1Ypc
• Name: glycogen synthase kinase 3 beta; targeted mutation 1.1, YiPing Chen
• MGI ID: MGI:4867288
• Synonyms: Gsk3beta^F
• Gene: Gsk3b Location: Chr16:37909363-38066446 bp, + strand Genetic Position: Chr16, 26.54 cM, cytoband B4
• Alliance: Gsk3b^tm1.1Ypc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166721
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:166721)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsk3b Mutation: 113 strains or lines available

References

• Original: J:166721 He F, et al., Gsk3beta is required in the epithelium for palatal elevation in mice. Dev Dyn. 2010 Dec;239(12):3235-46
• All: 3 reference(s)