Sirt6^tm2.2Cxd
Targeted Allele Detail

Summary

• Symbol: Sirt6^tm2.2Cxd
• Name: sirtuin 6; targeted mutation 2.2, Chu-Xia Deng
• MGI ID: MGI:4867398
• Synonyms: Sirt6^delta2-3
• Gene: Sirt6 Location: Chr10:81457621-81463631 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Sirt6^tm2.2Cxd page

Small body size of Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167023
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 3. Cre mediated recombination removed exons 2, exon 3, and the neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:167023)

Generation of the Sirt6^tm2.1Cxd and Sirt6^tm2.2Cxd alleles

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt6 Mutation: 41 strains or lines available

References

• Original: J:167023 Xiao C, et al., SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem. 2010 Nov 19;285(47):36776-84
• All: 3 reference(s)