Sirt6^tm2.1Cxd
Targeted Allele Detail

Summary

• Symbol: Sirt6^tm2.1Cxd
• Name: sirtuin 6; targeted mutation 2.1, Chu-Xia Deng
• MGI ID: MGI:4867399
• Synonyms: Sirt6^neo
• Gene: Sirt6 Location: Chr10:81457621-81463631 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Sirt6^tm2.1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167023
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: The loxP site inserted upstream of exon 2 was lost leaving a floxed neo cassette downstream of exon 3. The absence of protein expression was confirmed by western blot analysis. (J:167023)

Generation of the Sirt6^tm2.1Cxd and Sirt6^tm2.2Cxd alleles

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt6 Mutation: 41 strains or lines available

References

• Original: J:167023 Xiao C, et al., SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem. 2010 Nov 19;285(47):36776-84
• All: 1 reference(s)