Nlgn3^tm1.1Htz
Targeted Allele Detail

Summary

• Symbol: Nlgn3^tm1.1Htz
• Name: neuroligin 3; targeted mutation 1.1, Nathaniel Heintz
• MGI ID: MGI:4867464
• Gene: Nlgn3 Location: ChrX:100342785-100364956 bp, + strand Genetic Position: ChrX, 43.95 cM
• Alliance: Nlgn3^tm1.1Htz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167116
• Parent Cell Line: C2J (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The nucleotide sequence CGT in exon 6 which encodes Arginine at amino acid position 451 was modified to TGC which encodes Cysteine. A floxed neomycin cassette was also inserted in intron 6. The selection cassette was subsequently excised by crossing to Tg(EIIa-cre)C5379Lmgd mice. (J:167116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlgn3 Mutation: 36 strains or lines available

References

• Original: J:167116 Chadman KK, et al., Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice. Autism Res. 2008 Jun;1(3):147-58
• All: 2 reference(s)